Spreading of BETA-AMYLOID and TAU in organotypic brain slices (Supported by FWF Projekt P32558)
Alzheimer´s disease (AD) is characterized by beta-amyloid depositions in the brain (plaques) and vessels (cerebral amyloid angiopathy, CAA), tau pathology with intraneuronal neurofibrillary tangles (NFT), inflammation, cell death of cholinergic neurons and cerebrovascular dysfunction. We are interested to study how these pathologies can spread over the brain and where is the origin of the pathology. In order to study this question we will use well established organotypic brain slices.
Publications on SPREADING in BRAIN slices
In the final year of this FWF project Katharina Steiner studies spreading of beta-amyloid in a slice model linked to microcontact prints and we aim to study if beta-amyloid spreads in neurons and/or microglia and/or vessel.
Brain-on-a-chip technology (microcontact printing)
In a previous EU project "BrainMatTrain" we established the use of collagen hydrogels on brain slices and established microcontact printing (µCP) on slices.
| ||
 | | |
 | ||||
| ||||
| | | | |
